About Lipid RAFTs

A Paradigm Shift in Cell Biology

The cell membrane is the site of diverse molecular processes:

•   signal transduction
•   protein maturation
•   lipid and protein trafficking
•   cell-cell and cell-matrix interaction
•   endo- and exocytosis

Many disease events are related to these processes including those occurring in viral and bacterial infection, asthma, Alzheimer's disease, cancer and diabetes.

RAFTs are Integral to Many Disease Processes

RAFTs are dynamic and discrete membrane sub-compartments consisting of specific proteins and lipids. The RAFT provides a stabilized structure in which proteins are brought into close proximity in such a way that the interaction triggers an event. It is this event that JADO targets for pharmaceutical intervention.