Scientific Publications

Reviews

Rajendran L, Simons K. (2005) Lipid rafts and membrane dynamics. J Cell Sci. 118:1099-102.

Schuck S, Simons K. (2004)  Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane. J Cell Sci. 117:5955-64.

Fullekrug J, Simons K. (2004) Lipid rafts and apical membrane traffic. Ann N Y Acad Sci. 1014:164-9.

Simons K, Vaz WL. (2004) Model systems, lipid rafts, and cell membranes. Ann Rev Biophys Biomol Struct. 33:269-95.

Simons K, Ehehalt R. (2002) Cholesterol, lipid rafts, and disease. J Clin Invest.  110:597-603.

Allergy

Holowka D, Baird B. (2001) FceRI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells. Sem Immunol. 13:99–105.

Lafont F, Simons K. (2001) Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling. Proc Natl Acad Sci USA. 98:3180-4.

Influenza

Keller P, Simons K. (1998) Cholesterol is required for surface transport of influenza virus hemagglutinin. J Cell Biol. 140:1357-67.

Scheiffele P, Rietveld A, Wilk T, Simons K. (1999) Influenza viruses select ordered lipid domains during budding from the plasma membrane. J Biol Chem. 274:2038-44.

Scheiffele P, Roth MG, Simons K. (1997) Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J. 16:5501-8.

HIV/AIDS

Brügger B, Krautkrämer E, Tibroni N, Munte CE, Rauch S, Leibrecht I, Glass B, Breuer S, Geyer M, Kräusslich HG, Kalbitzer HR, Wieland FT, Fackler OT. (2007) Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology. 4:70.

Alzheimer’s disease

Lawrence Rajendran, Anja Schneider, Georg Schlechtingen, Sebastian Weidlich, Jonas Ries, Tobias Braxmeier, Petra Schwille, Jörg B. Schulz, Cornelia Schroeder, Mikael Simons, Gary Jennings, Hans-Joachim Knölker, Kai Simons.  (2008) Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting. Science 320: 520-523

Rajendran L, Knobloch M, Geiger KD, Dienel S, Nitsch R, Simons K, Konietzko U. (2007) Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes. Neurodegener Dis. 4:164-70.

Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, Simons K. (2006) Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci USA. 103:11172-77.

Kalvodova L, Kahya N, Schwille P, Ehehalt R, Verkade P, Drechsel D, Simons K. (2005) Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J Biol Chem. 280:36815-23.

Ehehalt R, Keller P, Haass C, Thiele C, Simons K.   (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts.
J Cell Biol. 160:113-23.

Rafts in other diseases

Simons K, Gruenberg J. (2000) Jamming the endosomal system: lipid rafts and lysosomal storage diseases. Trends Cell Biol. 10:459-62.

Kurzchalia T. (2003) Anthrax toxin rafts into cells. J Cell Biol. 160:295-6.

Raft chemistry

Schuck S, Honsho M, Ekroos K, Shevchenko A, Simons K. (2003) Resistance of cell membranes to different detergents. Proc Natl Acad Sci USA. 100:5795-800.

Simons M, Friedrichson T, Schulz JB, Pitto M, Masserini M, Kurzchalia TV. (1999) Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells. Mol Biol Cell. 10:3187-96.

Rietveld A, Neutz S, Simons K, Eaton S. (1999) Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. J Biol Chem. 274:12049-54.

Benting J, Rietveld A, Ansorge I, Simons K. (1999) Acyl and alkyl chain length of GPI-anchors is critical for raft association in vitro. FEBS Lett. 462:47-50.

Rietveld A, Simons K. (1998) The differential miscibility of lipids as the basis for the formation of functional membrane rafts. Biochim Biophys Acta. 1376:467-79. Review.

Friedrichson T, Kurzchalia TV. (1998) Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature. 394:802-5.

Shevchenko A, Keller P, Scheiffele P, Mann M, Simons K. (1997) Identification of components of trans-Golgi network-derived transport vesicles and detergent-insoluble complexes by nanoelectrospray tandem mass spectrometry. Electrophoresis. 18:2591-600.

Fiedler K, Kobayashi T, Kurzchalia TV, Simons K. (1993) Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells. Biochemistry. 32:6365-73.

Membrane dynamics

Vieira OV, Gaus K, Verkade P, Fullekrug J, Vaz WL, Simons K. (2006) From the Cover: FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells. Proc Natl Acad Sci USA. 103:18556-61.

Meder D, Moreno MJ, Verkade P, Vaz WL, Simons K. (2006) Phase coexistence and connectivity in the apical membrane of polarized epithelial cells. Proc Natl Acad Sci USA. 103:329-34.

Damm EM, Pelkmans L, Kartenbeck J, Mezzacasa A, Kurzchalia T, Helenius A. (2005) Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae. J Cell Biol. 168:477-88.

Poole K, Meder D, Simons K, Muller D. (2004) The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy. FEBS Lett. 565:53-8.

Bagnat M, Simons K. (2002)  Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. Biol Chem. 383:1475-80.

Lusa S, Blom TS, Eskelinen EL, Kuismanen E, Mansson JE, Simons K, Ikonen E. (2001) Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane. J Cell Sci.114:1893-900.

Bagnat M, Keranen S, Shevchenko A, Shevchenko A, Simons K. (2000) Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci USA. 97:3254-9.

Pralle A, Keller P, Florin EL, Simons K, Horber JK. (2000) Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J Cell Biol. 148:997-1008.

Harder T, Simons K. (1999) Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur J Immunol. 29:556-62.